CORDY

About Pentraxin3(PTX3/TSG-14)

  1. Top
  2. Antibody and reagent sales
  3. About Pentraxin3(PTX3/TSG-14)

PTX3, a member of the pentraxin family, is a long pentraxin.

The short pentraxin CRP belonging to the pentraxin family that is produced in the liver is a known arteriosclerosis marker and is elevated during infection. Therefore, CRP levels presumably reflect systemic and inflammatory reactions. In contrast to CRP, PTX3 is directly produced by macrophages involved in arteriosclerosis as well as by vascular endothelial cells, vascular smooth muscles, and neutrophils following stimulation with IL-1 or TNF.

PTX3 is associated with human heart disease and is a potential predictor of acute myocardial infarction. PTX3 level has been shown to increase during the early stages of myocardial infarction. Recent reports have suggested that PTX3 reduces vascular diseases occurring during sepsis and enables early detection of pulmonary hyperemia and is associated with bone metabolism.

References

  1. Lusis AJ. Nature. 2000 Sep 14;407(6801):233-41. (PMID: 11001066)
  2. Baumann H, et al. Immunol Today. 1994 Feb;15(2):74-80. (PMID: 7512342 )
  3. Steel DM, et al. Immunol Today. 1994 Feb;15(2):81-8. (PMID: 8155266 )
  4. Lee GW, et al. J Immunol. 1994 Oct 15;153(8):3700-7. (PMID: 7523502)
  5. Bottazzi B, et al. J Biol Chem. 1997 Dec 26;272(52):32817-23. (PMID: 9407058)
  6. Introna M, et al. Blood. 1996 Mar 1;87(5):1862-72. (PMID: 8634434)
  7. Basile A, et al. J Biol Chem. 1997 Mar 28;272(13):8172-8. (PMID: 9079634)
  8. Jaillon S, et al. J Exp Med. 2007 Apr 16;204(4):793-804. Epub 2007 Mar 26. (PMID: 17389238 )
  9. Latini R, et al. Circulation. 2004 Oct 19;110(16):2349-54. (PMID: 15477419)
  10. Peri G,et al. Circulation. 2000 Aug 8;102(6):636-41. (PMID: 10931803)
  11. Daigo K, et al. Sci Signal. 2014 Sep 16;7(343):ra88. (PMID: 25227610)
  12. Shirai Y, et al. Arthritis Rheumatol. 2015 Feb;67(2):498-507. (PMID: 25385504)
  13. Scimeca M, et al. Cell Death Dis. 2017 Oct 12;8(10):e3125. (PMID: 29022895)
  14. Garlanda C, et al. Annu Rev Immunol. 2005;23:337-66. (PMID: 15771574)
  15. Inoue K, et al. Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):161-7. (PMID: 17095712 )

PTX3 concentration in blood is expected as indicator for the degree of direct vascular inflammation.